I use MySQL and also sqlite. However, I also use Spring Python (http://
springpython.python-hosting.com) to use both its DatabaseTemplate
utility class and also the remoting functionality. This way, I can
have the database code sitting on the server, and then export the data
access functions remotely to clients. It is also relatively easy to
swap out database engines.

For the record: Spring Python is my pet project. I use it myself, and
recommend it to others as well.